effect of therapeutic dose of vitamin d on serum adiponectin and glycemia in vitamin d-insufficient or deficient type 2 diabetic patients

conclusions therapeutic dose of vitamin d can improve vitamin d status and glycemic indicators. but it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin d on serum adiponectin levels. results after 8-week intervention, serum 25-hydroxyvitamin d significantly increased and reached the normal levels in patients receiving vitamin d (p < 0.001) and the levels of fasting serum glucose, insulin, and homa-ir were significantly decreased (p = 0.04, 0.02 and 0.007, respectively). no significant changes were observed in these levels in the placebo group. significant differences were observed in mean changes in the above-mentioned variables between the two groups (p = 0.01, 0.04 and 0.006, respectively). no significant changes were found in serum adiponectin in the vitamin d and placebo groups (p = 0.83). objectives the aim of this study was to investigate the effect of therapeutic dose of vitamin d on serum adiponectin and insulin resistance in vitamin d-insufficient or deficient type 2 diabetic patients. materials and methods this double-blind, randomized, clinical trial was conducted on 81 type 2 diabetic patients with vitamin d level of 10-30 ng/ml. intervention was 50000 iu vitamin d or placebo once a week for 8 weeks. at the beginning and end of the study, blood samples were collected after 12 hours of fasting and serum glucose, insulin, 25-hydroxyvitamin d, and adiponectin were measured. insulin resistance was calculated by homeostasis model assessment (homa-ir). background lower vitamin d status has been reported in diabetic patients. serum 25-hydroxyvitamin d and adiponectin were inversely associated with type 2 diabetes and insulin resistance. vitamin d may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity.